Nkomo, Vuyisile T. and Arnett, Donna K. and Benjamin, Emelia J. and Liebson, Philip R. and Hutchinson, Richard G. and Skelton, Thomas N.
Objectives: To estimate prevalence of left ventricular (LV) hypertrophy and its relation to systolic function in a population-based sample of African Americans. Design: A baseline 2D guided M-mode echocardiogram was conducted as part of a longitudinal cohort study to assess prevalence and cross-sectional relationships between echocardiographic and clinical parameters. Setting: Data were collected as part of the Atherosclerosis Risk in Communities study. Participants: Analysis is limited to 1543 African Americans, aged 51±70 years, without clinically apparent cardiovascular or echocardiographically determined valvular disease. Main Outcome Measures: LV hypertrophy prevalence was de®ned as LV mass/ height2.7$51 g/m2.7. LV systolic chamber function was assessed at the midwall using the ratio of observed midwall fractional shortening (MWS%) to the value predicted from circumferential end-systolic stress. Results: The prevalence of LV hypertrophy was 33% in men, 38% in women. The prevalence of concentric hypertrophy (LV hypertrophy with relative wall thickness $0.45) was greater than that of eccentric hypertrophy (men: 24% vs 9%; women: 27% vs 11% women). Observed/predicted (O/P) MWS% was strongly and inversely related to LV mass/ height2.7 (P,.001) and LV hypertrophy (P,.001). The O/P MWS% was inversely related to LV mass/height2.7 quartile: O/P MWS% was 106% and 99% in the ®rst and 97% and 89% in the fourth quartile of LV mass/height2.7 for men and women, respectively. Adjusting for age, adiposity, diabetes, blood pressure, antihypertensive medication use, and smoking did not remove association between O/P MWS% and LV mass/height2.7. Conclusions: LV hypertrophy was highly prevalent in this population-based middle-aged sample of African Americans and was associated with poorer LV systolic chamber function.
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|Uncontrolled Keywords:||African Americans; Cohort Studies; Echocardiography; Left Ventricular Mass|
Research > studies
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|Date Deposited:||07 Dec 2008|
|Last Modified:||23 Jun 2011 17:01|
|Link to this item (URI):||http://health-equity.pitt.edu/id/eprint/1178|
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