Minority Health Archive

Left Ventricular Structure and Systolic Function in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Nkomo, Vuyisile T. and Arnett, Donna K. and Benjamin, Emelia J. and Liebson, Philip R. and Hutchinson, Richard G. and Skelton, Thomas N. (2004) Left Ventricular Structure and Systolic Function in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Ethnicity & Disease, 14 (4). pp. 483-488. ISSN 1049-510X

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Abstract

Objectives: To estimate prevalence of left ventricular (LV) hypertrophy and its relation to systolic function in a population-based sample of African Americans. Design: A baseline 2D guided M-mode echocardiogram was conducted as part of a longitudinal cohort study to assess prevalence and cross-sectional relationships between echocardiographic and clinical parameters. Setting: Data were collected as part of the Atherosclerosis Risk in Communities study. Participants: Analysis is limited to 1543 African Americans, aged 51±70 years, without clinically apparent cardiovascular or echocardiographically determined valvular disease. Main Outcome Measures: LV hypertrophy prevalence was de®ned as LV mass/ height2.7$51 g/m2.7. LV systolic chamber function was assessed at the midwall using the ratio of observed midwall fractional shortening (MWS%) to the value predicted from circumferential end-systolic stress. Results: The prevalence of LV hypertrophy was 33% in men, 38% in women. The prevalence of concentric hypertrophy (LV hypertrophy with relative wall thickness $0.45) was greater than that of eccentric hypertrophy (men: 24% vs 9%; women: 27% vs 11% women). Observed/predicted (O/P) MWS% was strongly and inversely related to LV mass/ height2.7 (P,.001) and LV hypertrophy (P,.001). The O/P MWS% was inversely related to LV mass/height2.7 quartile: O/P MWS% was 106% and 99% in the ®rst and 97% and 89% in the fourth quartile of LV mass/height2.7 for men and women, respectively. Adjusting for age, adiposity, diabetes, blood pressure, antihypertensive medication use, and smoking did not remove association between O/P MWS% and LV mass/height2.7. Conclusions: LV hypertrophy was highly prevalent in this population-based middle-aged sample of African Americans and was associated with poorer LV systolic chamber function.


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Item Type: Article
Additional Information: After clicking link, scroll down the page to find the article. Access to full text is subject to the publisher's access restrictions.
Uncontrolled Keywords: African Americans; Cohort Studies; Echocardiography; Left Ventricular Mass
Subjects: Health
Research
Research > studies
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Depositing User: Users 141 not found.
Date Deposited: 07 Dec 2008
Last Modified: 23 Jun 2011 17:01
Link to this item (URI): http://health-equity.pitt.edu/id/eprint/1178

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