Minority Health Archive

Differences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer

Latini, David M. and Elkin, Eric P. and Cooperberg, Matthew R. and Sadetsky, Natalia and DuChane, Janeen and Carroll, Peter R. (2006) Differences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer. Cancer, 106 (4). pp. 789-795. ISSN 0008-543X

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Abstract

BACKGROUND: Few studies of ethnicity and prostate cancer have included Latino men in analyses of baseline clinical characteristics, treatment selection, and disease-free survival (DFS). The present study examines the impact of Latino ethnicity on these parameters in a large, multiinstitutional database of men with prostate cancer. METHODS: We compared baseline disease characteristics and clinical outcomes for Latino (N = 138), non-Latino White (NLW, N = 5619), and African-American (AA, N = 608) men with localized prostate cancer by using chi-square and ANOVA for baseline variables and survival analysis to examine differences in time to recurrence. RESULTS: Latino men resembled AA men more than NLW on sociodemographic characteristics. AA men had higher Gleason scores and prostate-specific antigen (PSA) at diagnosis than Latino or NLW men (both P < 0.01). 10% of both Latino and AA men presented with advanced disease (T3b/T4/N+/M+) versus 4% of NLW (P < 0.01). Latino men did not receive different treatments than NLW or AA men after controlling for clinical and demographic factors; however, AA men were more likely to receive external beam radiation (OR = 1.51, 95% confidence interval [CI] = 0.99-2.31) and hormone treatment (OR = 1.56, 95% CI = 1.05-2.32) then NLW men. For prostatectomy patients, 3-year actuarial DFS rates were 83% for NLW men and 86% for Latino men versus 69% for AA men (P < 0.01). After controlling for clinical and sociodemographic variables, AA men were somewhat more likely than NLW to experience disease recurrence after radical prostatectomy (RP) (HR = 1.38, 95% CI = 0.98-1.94, P = 0.06). CONCLUSIONS: Latinos are more similar to African Americans on sociodemographic characteristics but more similar to NLW on clinical presentation, treatments received, and DFS.


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Item Type: Article
Additional Information: Full free text at publisher's website.
Uncontrolled Keywords: prostatic neoplasms;ethnicity;longitudinal analysis
Subjects: Health > Public Health > Chronic Illness & Diseases > Cancer
Research > studies
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Depositing User: Users 141 not found.
Date Deposited: 26 Jul 2011 10:02
Last Modified: 26 Jul 2011 10:02
Link to this item (URI): http://health-equity.pitt.edu/id/eprint/2854

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